⁃ Only patients with active lupus nephritis who meet all of the following criteria are eligible for inclusion in this study:

• Before random assignment, records show that it meets at least 4 of the 11 SLE classification criteria recommended by ACR in 1997.

• Age: age \> 18 years old, ≤ 65 years old when obtaining informed consent

• SLEDAI-2K score ≥ 6

• Urinary total protein / creatinine ratio \> 1.0 or 24-hour urinary protein \> 1.0g, with or without microscopic hematuria

• If they are fertile, they must agree to use effective contraception during the trial.

• In the case of women of childbearing age, urinary pregnancy and serum pregnancy tests should be negative.

• Voluntarily sign informed consent and comply with the requirements of the research programme